In vitro cell-based assays to test drugs – A review

Samrot, Antony V. and Wilson S and Subramanian, Saigeetha and Rajan Renuka, Remya and Subramonian, Sivarao (2025) In vitro cell-based assays to test drugs – A review. Applied Chemical Engineering, 8 (4). pp. 1-22. ISSN 2578-2010

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Abstract

Cell viability is an important indicator of healthy cells. Cell viability plays a prominent role in order to determining various parameters including toxicity, as the cells may be damaged due to some physical and chemical agents. In vitro assays are efficient, sensitive, time-saving and were designed to replace the problems and ethical issues faced by animal models for testing the efficiency of a drug molecule. There are various assays used for determining the cell viability in eukaryotes. Assays, including Dye exclusion assays, colorimetric assays, luminometric assays, fluorometric assays and DNA-based assays involved in determining the cell viability, proliferation and cytotoxicity are discussed in this review.

Item Type:	Article
Uncontrolled Keywords:	In vitro assays, Tetrazolium salts, Resazurin, DNA based assays
Divisions:	Faculty Of Industrial And Manufacturing Technology And Engineering
Depositing User:	Sabariah Ismail
Date Deposited:	20 Jul 2026 07:07
Last Modified:	20 Jul 2026 07:07
URI:	http://eprints.utem.edu.my/id/eprint/30017
Statistic Details:	View Download Statistic

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