Explainable ai for Alzheimer detection: A review of current methods and applications

Al-Andoli, Mohamed Nasser and Hasan Saif, Fatima and Wan Bejuri, Wan Mohd Ya'akob (2024) Explainable ai for Alzheimer detection: A review of current methods and applications. Applied Sciences, 14 (22). pp. 1-21. ISSN 2076-3417

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Abstract

Alzheimer’s disease (AD) is the most common cause of dementia, marked by cognitive decline and memory loss. Recently, machine learning and deep learning techniques have introduced promising solutions for improving AD detection through MRI, especially in settings where specialists may not be readily available. These techniques offer the potential to assist general practitioners and non-specialists in busy clinical environments. However, the ‘black box’ nature of many AI techniques makes it challenging for non-expert physicians to fully trust their diagnostic accuracy. In this review, we critically evaluate current explainable AI (XAI) methods applied to AD detection and highlight their limitations. In addition, a new interpretability framework, called “Feature-Augmented”, was theoretically designed to improve model interpretability. This approach remains underexplored, primarily due to the scarcity of explainable AD-specific datasets. Furthermore, we underscore the importance of AI models being accurate and explainable, which enhance diagnostic confidence and patient care outcomes.

Item Type:	Article
Uncontrolled Keywords:	Alzheimer’s disease, Artificial intelligence, Machine learning, Deep learning, Explainable AI, Convolutional neural networks, MRI, Clinical decision
Divisions:	Faculty of Information and Communication Technology
Depositing User:	Sabariah Ismail
Date Deposited:	05 Jun 2025 08:37
Last Modified:	05 Jun 2025 08:37
URI:	http://eprints.utem.edu.my/id/eprint/28705
Statistic Details:	View Download Statistic

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