Hashim, Hashemi (2025) Pre-clinical evaluation of early osteoarthritis via biomechanical properties derived from low field MRI. Masters thesis, Universiti Teknikal Malaysia Melaka.
![[img]](http://eprints.utem.edu.my/style/images/fileicons/text.png) |
Text (Full Text)
Pre-clinical evaluation of early osteoarthritis via biomechanical properties derived from low field MRI.pdf - Submitted Version Available under License Creative Commons Attribution. Download (3MB) |
Abstract
Osteoarthritis is a degenerative disease which is associated with the articular cartilage in the synovial joint. As the disease progresses, it changes the macromolecular structure inside the cartilage tissue and alters the biomechanical properties. Hence, the ability to detect the disease at its earliest grade is crucial for early intervention of the disease. The osteoarthritis is clinically diagnosed using Magnetic Resonance Imaging (MRI) by examining the morphology of the articular cartilage and the geometrical data of the synovial joint. However, most of the diagnoses were performed when this disease is already progressed into advanced grade. At early grade of osteoarthritis, the biomechanical properties start to show noticeable change. Although studies were conducted to correlate the biomechanical properties of cartilage with MRI image, high-field MRI was utilized to produce the cartilage image. Therefore, this study aimed to investigate the potential use of low-field MRI to monitor the biomechanical properties of articular cartilage. This includes to determine the greyscale of low-field MRI image, characterize the biomechanical properties of articular cartilage and finally to observe the correlation between the greyscale and biomechanical properties of articular cartilage from fibrillated cartilage sample. Cartilages from hip joints of bovine were scanned using 0.18 T MRI. The images of cartilage were characterized based on the intensity of the greyscale. Creep indentation test was then conducted on the cartilage specimens and subsequently the indentation test was simulated using finite element method. The biomechanical properties of Elastic Modulus and Permeability of cartilage were characterized by incorporating the experimental data from the indentation test with the computational finite element model. The mean Elastic Modulus was found to be 0.26 ± 0.07 while the Permeability was 5.26 ± 1.72×10⁻¹⁵ m⁴/Ns. Further correlation analyses were performed to examine the relationship between the greyscale of MRI image and biomechanical properties of Elastic Modulus and Permeability of the cartilage. Good correlation was found between the cartilage greyscale and cartilage biphasic Elastic Modulus (r= 0.74) and a strong correlation with negative value was observed between the cartilage greyscale and cartilage Permeability (r= -0.86). Hence, present results indicate that the low-field MRI has potential for non-invasive assessment of the condition of articular cartilage. It could be further developed to serve as an early intervention of osteoarthritis disease. However further validation using human samples is necessary before clinical application.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Articular Cartilage, Osteoarthritis, Low-field MRI, Biomechanical properties, Indentation test |
| Subjects: | T Technology T Technology > TK Electrical engineering. Electronics Nuclear engineering |
| Divisions: | Library > Tesis > FTKIP |
| Depositing User: | Norhairol Khalid |
| Date Deposited: | 17 Mar 2026 07:14 |
| Last Modified: | 17 Mar 2026 07:14 |
| URI: | http://eprints.utem.edu.my/id/eprint/29653 |
| Statistic Details: | View Download Statistic |
Actions (login required)
 |
View Item |